Twin and family studies have shown that genetic factors contribute to osteoporosis by influencing bone mineral density (BMD), and other phenotypes that are associated with fracture risk, although the heritability of fracture itself is modest.
Background: Osteoporosis is an age-associated disease, which is influenced by genetic, epigenetic and environmental factors.
What percentage of osteoporosis is genetic?
Studies on osteoporosis sibs and families demonstrated that genetic factors are responsible for about 60–85% of inter-individual variability of bone mineral density (BMD) [1, 2], and this effect appears to persist even in the late decades of life. BMD heritability varies between different skeletal sites .
Does having osteoporosis shorten your life?
The residual life expectancy of a 50-year-old man beginning osteoporosis treatment was estimated to be 18.2 years and that of a 75-year-old man was 7.5 years. Estimates in women were 26.4 years and 13.5 years, respectively.
Is type 2 diabetes a single gene disease?
A multinational study has identified a key gene mutation responsible for type 2 diabetes in nearly 10 percent of patients of white European ancestry.
What are the two medications that may cause osteoporosis after long term use?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
What happens if osteoporosis is left untreated?
Osteoporosis left untreated increases the likelihood of fractures. Simple actions such as sneezing or coughing, making a sudden turn, or bumping into a hard surface can result in a fracture. This can make you feel like you’re walking on eggshells and cause you to refrain from participating in activities that you enjoy.
Is sitting bad for osteoporosis?
“If you have low bone density, however, and you put a lot of force or pressure into the front of the spine — such as in a sit-up or toe touch — it increases your risk of a compression fracture.” Once you have one compression fracture, it can trigger a “cascade of fractures” in the spine, says Kemmis.
Is osteoporosis a single gene disease?
Osteoporosis is a polygenic disorder, determined by the effects of several genes, each with relatively modest effects on bone mass and other determinants of fracture risk. It is only on rare occasions that osteoporosis occurs as the result of mutations in a single gene.
Should I worry if I have osteoporosis?
Talk with your doctor about an earlier scan if you have any warning signs or risk factors for osteoporosis: a bone fracture after age 50. sudden back pain. loss of height or increasingly stooped posture.
What organs are affected by osteoporosis?
Osteoporotic bone breaks are most likely to occur in the hip, spine or wrist, but other bones can break too. In addition to causing permanent pain, osteoporosis causes some patients to lose height. When osteoporosis affects vertebrae, or the bones of the spine, it often leads to a stooped or hunched posture.
At what age should I be tested for osteoporosis?
Currently, screening for osteoporosis is recommended for women who are 65 years old or older and for women who are 50 to 64 and have certain risk factors, which include having a parent who has broken a hip. You can use the FRAX Risk Assessment tool to learn if you should be screened.