How does type 1 diabetes cause osteoporosis?

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Does Type 1 diabetes affect bone density?

The diabetes–osteoporosis link

It is possible that people with type 1 diabetes achieve lower peak bone mass, the maximum strength and density that bones reach. People usually reach their peak bone mass in their 20s. Low peak bone mass can increase one’s risk of developing osteoporosis later in life.

Why does diabetes cause osteoporosis?

Diabetes mellitus (DM) increases osteoclast function but decreases osteoblast function, thereby leading to accelerated bone loss, osteopenia and osteoporosis.

How does insulin deficiency cause osteoporosis?

Higher glucose levels in the blood are known to interact with several proteins to form advanced glycation end (AGE) products. Yamagishi et al hypothesized that AGE-products in collagen may interact with bone to reduce bone strength, resulting in osteoporosis in patients with diabetes.

Does insulin affect bone density?

Insulin use was found to be associated with greater bone mineral density loss at the femoral neck among women with diabetes mellitus.

Do diabetics have brittle bones?

What is it? Osteoporosis is a disorder that causes bones to become weak and prone to fracture. People who have type 1 diabetes have an increased risk of osteoporosis.

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Do diabetics have weak bones?

The review found that fractures of the hip, arm, foot, and spine are all more common in people with diabetes. The susceptibility to osteoporosis is due to many factors, including bone mineral density (BMD). Type 1 diabetes causes a loss of BMD, which links it to osteoporosis and generally weaker bones.

Is type 2 diabetes a risk factor for osteoporosis?

Individuals with Type 1 diabetes (the loss of insulin produced by the pancreas) or Type 2 diabetes (the body’s inability to use insulin and a slow loss of one’s ability to make insulin) have an increased risk of bone fractures and osteoporosis.

Does sugar affect osteoporosis?

However, the other ubiquitous white crystal, sugar, may lead to osteoporosis by increasing inflammation, hyperinsulinemia, increased renal acid load, reduced calcium intake, and increased urinary calcium excretion. Sugar, not salt, is the more likely white crystal to be a risk factor for osteoporosis when overconsumed.

What medical research indicates that there might be a relationship between diabetes and osteoporosis?

The review of 12 studies showed that people with Type 2 diabetes are 70% more likely to fracture their hip and in the review of 6 studies, those with Type 1 over 6 times more likely to do so.

How does hyperthyroidism affect bones?

Overt hyperthyroidism is associated with accelerated bone remodeling, reduced bone density, osteoporosis, and an increase in fracture rate. The bone density changes may or may not be reversible with therapy.

What is osteoblast and osteoclast?

Osteoblast and osteoclast are the two main cells participating in those progresses (Matsuo and Irie, 2008). Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions.

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