Can statins affect bone density?
Several observational cohort and meta-analytical studies in humans have shown that statin users have a lower risk of fractures or greater bone mineral densities (BMD) than nonusers. However, some studies including randomized clinical trials have the opposite results, particularly in Asian populations.
What medications make osteoporosis worse?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
What do statins do to your bones?
Some research has found the statins lead to an increase in bone formation and inhibit bone resorption via reducing osteoclastogenesis,3 according to Mattias Lorentzon, MD, PhD, professor, and head of geriatric medicine at the Institute of Medicine of Sahlgrenska Academy and Sahlgrenska University Hospital in Molndal, …
Do statins make your bones ache?
Statins can cause muscle aches, or myalgia, in 7% of people taking them. But even though they shouldn’t cause joint aches, studies suggest certain statin users are more likely to have joint aches.
Which statin has the least amount of side effects?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
Should I take calcium with statins?
Interactions between your drugs
No interactions were found between Calcium 600 D and simvastatin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can osteoporosis be treated without medication?
Many people prefer not to take drugs or medications because they want to treat their osteoporosis “naturally,” but at this time, there are no herbal supplements or “natural” treatments that are proven to be both safe and effective to treat osteoporosis and prevent broken bones.
Which type of statin therapy is associated with an increased likelihood of being diagnosed with osteoporosis?
However, risk for osteoporosis increased among those taking higher doses of statins, defined as doses exceeding 40 mg for simvastatin (OR, 1.64; P < . 01) and exceeding 20 mg for atorvastatin (OR, 1.78; P < . 01) and rosuvastatin (OR, 2.04; P < . 01), compared to control persons.
What is the safest osteoporosis drug 2020?
The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture).
What is the life expectancy of a person with osteoporosis?
The average life expectancy of osteoporosis patients is in excess of 15 years in women younger than 75 years and in men younger than 60 years, highlighting the importance of developing tools for long-term management.
Do statins affect calcium levels?
Evidence supports the idea that statin therapy not only reduces cholesterol levels but also changes existing plaques to make them less dangerous. As part of this process, the plaques may become more calcified—and thus, calcium score goes up.
Are bone density and bone strength the same thing?
This important study has been nearly forgotten, but it remains the most clear-cut evidence that bone density is not the same as bone strength. A decade later, a large randomized trial in osteoporosis (N = 9331) compared placebo to 2 doses of the bisphosphonate risedronate (5 mg/d and 2.5 mg/d).
Does atorvastatin affect calcium levels?
Our report demonstrated alterations in calcium metabolism, while taking atorvastatin cal- cium include increased calcium in the blood.