Can statins cause tendon damage?
Current statin use seems to increase the risk of trigger finger and shoulder tendinopathy, possibly through increased MMP release, and subsequently, a weakened tendon matrix which will be more prone to injuries.
What medication causes tendon rupture?
The new warnings apply to fluoroquinolones, a class of antibiotics that includes the popular drug Cipro. The FDA has told companies that the drugs must now carry “black box” warnings alerting doctors and patients that the drugs can increase risk of tendinitis and tendon rupture in some patients.
Can statins cause ligament damage?
Tendon ruptures and other tendon injuries have not been reported as a side effect of statin use in previous studies, but there have been anecdotal reports of a link over the years, appearing mostly in French medical journals.
Can statins cause muscle rupture?
Data from spontaneous reporting systems suggest that use of statins is associated with muscle rupture. Physicians and patients should be aware that this can occur. musculoskeletal side effects vary from temporarily disabling muscle cramps and myalgia to serious and life-threatening rhabdomyolysis.
Is there a non statin cholesterol medication?
There are many non-statin medications your doctor might prescribe: Bile acid-binding resins, like cholestyramine (Locholest, Prevalite, Questran), colesevelam (WelChol), and colestipol (Colestid) stick to cholesterol-rich bile acids in your intestines and lower your LDL levels.
Which statin has the least amount of side effects?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
What is the risk of tendon rupture with ciprofloxacin?
In a study with prescription event monitoring, the incidence of tendon rupture was estimated as 2.7 per 10 000 patients for ofloxacin and 0.9 per 10 000 patients for ciprofloxacin.
Which antibiotics are bad for tendons?
The first antibiotic to be linked to tendonitis is the group known as fluoroquinolones. Some of the common antibiotic names in this group include ciprofloxacin and levofloxacin. Other antibiotics known to increase the risk of tendonitis include clindamycin or azithromycin.
How do I know if my tendon is torn?
An injury that is associated with the following signs or symptoms may be a tendon rupture:
- A snap or pop you hear or feel.
- Severe pain.
- Rapid or immediate bruising.
- Marked weakness.
- Inability to use the affected arm or leg.
- Inability to move the area involved.
- Inability to bear weight.
- Deformity of the area.
What can be taken instead of statins?
7 cholesterol-lowering alternatives to statins
- Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. …
- Plant stanols and sterols. …
- Cholestyramine and other bile acid-binding resins. …
- Niacin. …
- Policosanol. …
- Red yeast rice extract (RYRE) …
- Natural products.
Do statins reduce collagen?
In conclusion, this study suggests that therapy with statins in patients with coronary artery disease and atrial fibrillation is associated with an increase in collagen degradation and an attenuation of inflammation, independently of cholesterol lowering.
Can muscle damage from statins be reversed?
The damage is typically reversible once the person stops taking the statin. More rarely still, a severe type of muscle damage called rhabdomyolysis may occur, in an estimated 2–3 in 100,000 people taking this type of drug per year.