How effective are bisphosphonates for osteoporosis?

Is bisphosphonates good for osteoporosis?

Bisphosphonates can be administered orally or intravenously with a wide range of doses and dosing intervals. Randomized placebo-controlled clinical trials have shown that bisphosphonates reduce fracture risk in postmenopausal women with osteoporosis and have a generally excellent safety record.

Can bisphosphonates reverse osteoporosis?

“You can slow down the bone loss, [but] it’s not the same as reversing it,” says Nieves, who also works at New York’s Helen Hayes Hospital. There are several types of osteoporosis drugs, which are available by prescription only: Bisphosphonates, such as Fosamax, Boniva, Actonel, and Reclast.

Do bisphosphonates strengthen bone?

Bisphosphonates work by slowing down the cells which break down bone (osteoclasts). Therefore they slow down bone loss, allowing the bone building cells (osteoblasts) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.

What is the most effective bisphosphonate?

Oral – We suggest alendronate or risedronate as the initial choice of oral bisphosphonate (table 1). We most commonly use alendronate, in part due to direct evidence showing residual fracture benefit in selected patients after completing a five-year course of therapy [1].

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Is sitting bad for osteoporosis?

“If you have low bone density, however, and you put a lot of force or pressure into the front of the spine — such as in a sit-up or toe touch — it increases your risk of a compression fracture.” Once you have one compression fracture, it can trigger a “cascade of fractures” in the spine, says Kemmis.

What are the two medications that may cause osteoporosis after long term use?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.

Can vitamin D reverse osteoporosis?

In the 8 studies with greater than 80% compliance, a 24% risk reduction for all fractures was identified. The author’s conclusions were that calcium, or calcium in combination with vitamin D supplementation, was effective in the preventive treatment of osteoporosis in people aged 50 years or older.

What is the best form of calcium to take for osteoporosis?

The two most commonly used calcium products are calcium carbonate and calcium citrate. Calcium carbonate supplements dissolve better in an acid environment, so they should be taken with a meal. Calcium citrate supplements can be taken any time because they do not need acid to dissolve.

Who should not take bisphosphonates?

Don’t take bisphosphonates if you:

  • Are allergic to them.
  • Have disorders of the food pipe (esophagus), including tears, holes, narrowing, or difficulty swallowing.
  • Have severe kidney disease.
  • Can’t sit in an upright position for at least 30 minutes.
  • Have low levels of calcium in your bloodstream.
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How long should you stay on bisphosphonates?

Answer From Ann Kearns, M.D., Ph. D. Bisphosphonates, the most common type of osteoporosis medications, are typically taken for at least 3 to 5 years. After that, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications.

What happens when you stop taking bisphosphonates?

Bisphosphonates bind to bone, and when a patient stops using them after 10 years of treatment, they lose an estimated 2.5 mg per day. “This is not like many drugs we use,” he said.