Frequent question: Why bisphosphonate administration is helpful in osteoporosis?

Why is bisphosphonates the drug of choice for osteoporosis?

Bisphosphonate therapy normalizes bone turnover, reduces the number of bone remodeling sites and stress risers, restores the balance of bone remodeling, prevents bone loss and deterioration of bone structure and, in patients with osteoporosis, reduces fracture risk (5).

When are bisphosphonates used in osteoporosis?

Use immediately after fracture — A history of a fragility (low-trauma) fracture is an important risk factor for subsequent fracture. If a patient is not already treated, pharmacologic therapy (typically bisphosphonates) should be initiated in patients with fragility fracture to prevent subsequent fracture [71].

Is sitting bad for osteoporosis?

“If you have low bone density, however, and you put a lot of force or pressure into the front of the spine — such as in a sit-up or toe touch — it increases your risk of a compression fracture.” Once you have one compression fracture, it can trigger a “cascade of fractures” in the spine, says Kemmis.

What are the two medications that may cause osteoporosis after long term use?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.

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What is the safest osteoporosis drug 2020?

The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture).

How long should you stay on bisphosphonates?

Answer From Ann Kearns, M.D., Ph. D. Bisphosphonates, the most common type of osteoporosis medications, are typically taken for at least 3 to 5 years. After that, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications.

Who should not take bisphosphonates?

Don’t take bisphosphonates if you:

  • Are allergic to them.
  • Have disorders of the food pipe (esophagus), including tears, holes, narrowing, or difficulty swallowing.
  • Have severe kidney disease.
  • Can’t sit in an upright position for at least 30 minutes.
  • Have low levels of calcium in your bloodstream.

What happens when you stop taking bisphosphonates?

Bisphosphonates bind to bone, and when a patient stops using them after 10 years of treatment, they lose an estimated 2.5 mg per day. “This is not like many drugs we use,” he said.

What are the risks of taking bisphosphonates?

Side effects for all the bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid) may include bone, joint or muscle pain. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus (tube connecting the throat to the stomach) and gastric ulcer.

How quickly do bisphosphonates work?

It takes several months for bisphosphonates to work. Usually there is an increase in bone density 6-12 months after you start taking one. This then helps to prevent breaks (fractures) of the spine, the hip, and other bones such as the wrist.

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Are bananas good for osteoporosis?

As all these nutrients play an essential role for your health, they also improve your bone density. Eat pineapple, strawberries, oranges, apples, bananas and guavas. All these fruits are loaded with vitamin C, which in turn, strengthen your bones.

What is the best sleeping position for osteoporosis?

What’s the best sleeping position for osteoporosis of the spine? Sleeping on your side or back are both viewed as suitable for those with brittle bones. You may want to avoid sleeping on your stomach because it can cause too much of an arch in the back, which is both unhealthy and uncomfortable.

How should you sleep with osteoporosis?

Lying Down and Getting Out of Bed

  1. When lying on your side in bed, use one pillow between your knees and one under your head to keep your spine aligned and increase your comfort.
  2. When lying on your back in bed, use one or two pillows under your knees and one under your head.