Why is alkaline phosphatase elevated in bone disease?
Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia.
Is ALP high in osteoporosis?
Biver, et al. has also showed raised levels of bone alkaline phosphatase in osteoporotic patients compared to normal, and these high levels may be associated with prevalent vertebral fractures.
Can osteoarthritis cause high alkaline phosphatase?
In this nationally representative cross-sectional study, we found that higher serum ALP levels were positively associated with the presence of radiologically confirmed symptomatic knee osteoarthritis in middle-aged and old adults.
Should I be concerned if my alkaline phosphatase is high?
While alkaline phosphatase may not necessarily cause harm to the body itself, elevated levels are associated with cancer, bone, liver, and kidney diseases . Additionally, lifestyle factors, medication, and certain supplements can raise alkaline phosphatase levels.
When should I worry about alkaline phosphatase?
Abnormal levels of ALP in your blood most often indicate a problem with your liver, gallbladder, or bones. However, they may also indicate malnutrition, kidney cancer tumors, intestinal issues, a pancreas problem, or a serious infection.
What is considered a high alkaline phosphatase level?
ALP results are reported in units per liter (U/L). For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly.
How do high levels of alkaline phosphatase indicate a bone abnormality?
Instead, it can indicate a bone disorder, such as Paget’s Disease of Bone, a condition that causes your bones to become abnormally large, weak, and prone to fractures. Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection.
What is considered extremely high ALP?
Extremely high levels of ALP were defined as being more than 1000 U/L. These patients were divided into different groups according to their final diagnosis.
What is the most accurate test for osteoporosis?
A bone density test is the only test that can diagnose osteoporosis before a broken bone occurs. This test helps to estimate the density of your bones and your chance of breaking a bone. NOF recommends a bone density test of the hip and spine by a central DXA machine to diagnose osteoporosis.
What is ALP normal range?
The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and sex. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.
What medications can cause elevated alkaline phosphatase?
Some examples of drugs that may cause a raised alkaline phosphatase include:
- Antibiotics: penicillin derivatives (1) …
- Antiepileptic drugs: Carbamazepine. …
- Antihistamines: Cetirizine (1)
- Cardiovascular drugs: Captopril (1) …
- Disease modifying agents: …
- Polycyclic aromatic hydrocarbons: …
- Psychotropic drugs: …
- Diabetes drugs:
Can arthritis cause high alkaline phosphatase levels?
Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear. The aim of this study is to analyze the origin and clinical significance of the elevated ALP value in RA.
Can inflammation cause high alkaline phosphatase?
Elevated levels are also associated with diabetes, hypertension, and cardiovascular disease; it was found that elevated levels are associated with elevated serum C-reactive protein (CRP), which could reflect an inflammatory and atherogenic milieu, possibly an alternative cause for elevated serum alkaline phosphatase.
Can NSAIDs increase alkaline phosphatase?
Serum alkaline phosphatase concentrations are not influenced by NSAIDs.