How do genetics play a role in osteoporosis?

How much does genetics play a role in bone density?

Genetic factors have long been recognized as playing an important role in the pathogenesis of osteoporosis. Evidence from twin and family studies suggests that between 50% and 85% of the variance in peak bone mass is genetically determined, depending on skeletal site and the age of the subjects studied (Smith et al.

How does genetics affect bone health?

More than 40 million people nationwide either have osteoporosis or are at increased risk for broken bones because of low bone mineral density (osteopenia). Past studies suggest that genetic differences may account for more than half the variance in bone mineral density between people.

Is osteoporosis genetic or environmental?

Osteoporosis is partly genetically determined. The genetics of osteoporosis is polygenic in nature with multiple common polymorphic alleles interacting with each other and environmental factors to determine bone mass.

What is the significance of genetics and ethnicity as a risk factor of osteoporosis?

Differences in body size. People of Asian descent tend to have smaller body frames than those of other ethnicities, and people who are shorter and more slender are at increased risk of developing osteoporosis. Calcium intake. A diet low in calcium and vitamin D increases the odds of developing osteoporosis.

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Can bone density affect weight?

Body weight is directly associated with bone mineral density (BMD). … On the other hand, a high body weight can be due to increased physical activity or obesity, and both will increase BMD, but there is increasing evidence that excess weight due to adiposity is detrimental to bone and fracture risk.

Can you inherit strong bones?

A new study indicates that bone strength may be inherited and that its genetic determinants are to some extent shared with bone mineral density. A new study indicates that bone strength may be inherited and that its genetic determinants are to some extent shared with bone mineral density.

Does having osteoporosis shorten your life?

The residual life expectancy of a 50-year-old man beginning osteoporosis treatment was estimated to be 18.2 years and that of a 75-year-old man was 7.5 years. Estimates in women were 26.4 years and 13.5 years, respectively.

What can be done to prevent osteoporosis?

There are things you should do at any age to prevent weakened bones. Eating foods that are rich in calcium and vitamin D is important. So is regular weight-bearing exercise, such as weight training, walking, hiking, jogging, climbing stairs, tennis, and dancing.

How can you prevent hereditary osteoporosis?

Prevention of osteoporosis

  1. have a healthy and varied diet with plenty of fresh fruit, vegetables and whole grains.
  2. eat calcium-rich foods.
  3. absorb enough vitamin D.
  4. avoid smoking.
  5. limit alcohol consumption.
  6. limit caffeine.
  7. do regular weight-bearing and strength-training activities.

How does environment affect osteoporosis?

Exposure to air pollution increases the risk of osteoporosis: a nationwide longitudinal study. Furthermore, exposure to lead and cadmium is adversely associated with BMD and fracture risk.

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What ethnic group is most affected by osteoporosis?

Osteoporosis can occur in persons of all races and ethnicities. In general, however, whites (especially of northern European descent) and Asians are at increased risk. In particular, non-Hispanic white women and Asian women are at higher risk for osteoporosis.

What is the most common drug used to treat osteoporosis?

For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates. Examples include: Alendronate (Binosto, Fosamax) Ibandronate (Boniva)

Which client is most at risk for osteoporosis?

Women over the age of 50 are the most likely people to develop osteoporosis. The condition is 4 times as likely in women than men. Women’s lighter, thinner bones and longer life spans are part of the reason they have a higher risk. Men can get osteoporosis, too — it’s just less common.